Last updated: September 23, 2026 [Key Takeaways] Colds and the flu are caused by viruses, and antibiotics are designed to act on bacteria, so they have no mechanism for shortening a viral illness. Every unnecessary course of antibiotics applies selective pressure that helps resistant bacteria survive and spread, a core driver of antibiotic resistance. Antibiotic-resistant infections are linked to more than 35,000 deaths in the United States each year and represent a growing public health burden. When a doctor declines to prescribe antibiotics for a cold, evidence-based supportive care — fluids, rest, over-the-counter symptom relief, and nasal saline — can still ease symptoms. If antibiotics are prescribed for a confirmed bacterial infection, taking them exactly as directed and not stopping early on your own helps treat the infection fully and lowers the chance of relapse — the right course length is a decision for the prescribing clinician, not a general rule for preventi...
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